All combinations of factors from the ABCD and California scores were tested for their c statistic, and the combination with the highest statistic for 2-day risk of stroke was selected and validated. The c statistic was calculated to measure predictive ability. Study cohorts were drawn from the Kaiser-Permanente Medical Care Plan in Northern California, United States and from Oxfordshire, United Kingdom. Moreover, the score has been shown to be predictive of carotid embolic sources, but less useful for cardiac sources of emboli. Some have criticized the ABCD2 score for only taking into account clinical features and not giving any consideration to investigations. While its c statistic is similar to those of the ABCD and California scores, the ABCD2 score has been more widely validated and has been shown to accurately predict the risk of stroke at 2, 7, and 90 days following a TIA. Since its publication, the ABCD2 score has become widely used by front-line healthcare providers to risk stratify patients with TIA and determine how urgently these patients should be seen for subsequent assessment and treatment. Study Rundown:The ABCD2 score is a seven-point score for identifying patients who have suffered a transient ischemic attack (TIA) at the highest risk of stroke in the following 2-day period. This study summary is an excerpt from the book 2 Minute Medicine’s The Classics in Medicine: Summaries of the Landmark Trials, 1e (The Classics Series).
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